using a 3D-capillary bioreactor any lab can continuously maintain a very large number of mammalian cells on the shelf of an incubator and produce multiple harvests of supernatant with exceptionally high yields of cell-secreted product
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Publications referring to FiberCell System
Access lists of relevant references / Extracellular vesicles production / Monoclonal antibodies production / Recombinant proteins production / Secretome from 3D cultures
YouTube video about CDM-HD
CDM-HD : chemically-defined media for high density culture Once cells are growing at high density in a FiberCell bioreactor it is generally very easy to switch over to CDM-HD [...]
July 2020 publication refers to EV production in hollow fibre bioreactor
Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming Alek Mazumdar et al., Dept. of Orthopedics, Balgrist University Hospital, Zurich, Switzerland; Int. J. Mol. Sci. 2020, 21, 5451; doi:10.3390/ijms21155451 "....our findings [...]
FiberCell Applications
A FiberCell hollow fibre bioreactor is a compact and affordable high cell density culture system aimed at academic and commercial labs that need to produce significant quantities of mAb, protein, exosomes or virus.
Other applications include antimicrobial PK/PD modelling, production of conditioned media, cell secretome, co-culture models, cultivation of cells within fibres under flow and long-term 3D in vitro models (e.g. long term gut model).
Compact Hollow Fibre Bioreactor
Maintain >10^9 cells in continuous culture on one shelf of a standard incubator
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Monoclonal antibody production
Continuous culture of 10^9 hybridomas in a 20ml hollow fibre cartridge on the shelf of a standard incubator [more]
Extracellular vesicle production
3-Capillary Bioreactor conditions are ideal for continuously culturing MSCs or cell lines and taking repeated harvests of very concentrated EVs [more].
Recombinant protein production
Looking to produce a difficult-to-express protein? A Medium Size hollow fibre cartridge (20ml) can generate 2mg per day over many weeks, even months, with 50 x better yield than traditional static flask culture. [more].
Hollow fibre cartridge modules
Pre-sterilized, single-use hollow fibre cartridge modules 3ml, 20ml and 70ml, available in 5 kD, 20 kD MWCO. Special 0.1 µm endothelial cell cartridge also available. [learn more].
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