using a 3D-capillary bioreactor you can continuously maintain a very large number of mammalian cells on the shelf of an incubator and produce multiple supernatant harvests with exceptionally high yields of cell-secreted product

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July 2020 publication refers to EV production in hollow fibre bioreactor

Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming Alek Mazumdar et al., Dept. of Orthopedics, Balgrist University Hospital, Zurich, Switzerland; Int. J. Mol. Sci. 2020, 21, 5451; doi:10.3390/ijms21155451 "....our findings [...]

In pursuit of biological specificity

Which culture method is best to generate reagents with native biological specificity? Cell culture methods vary a lot with respect to their ability to generate secreted proteins and antibodies [...]

SARS-CoV-2 and hollow fibre bioreactor culture

Here's how hollow fibre culture could be useful for Coronavirus research. FIRSTLY - Efficient routine production (100mg to grams) of recombinant viral proteins and monoclonal antibodies for TEST [...]

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FiberCell Applications

A FiberCell hollow fibre bioreactor is a compact and affordable high cell density culture system aimed at academic and commercial labs that need to produce significant quantities of mAb, protein, exosomes or virus.

Other applications include antimicrobial PK/PD modelling, production of conditioned media, cell secretome, co-culture models, cultivation of cells within fibres under flow and long-term 3D in vitro models (e.g. long term gut model).

Compact Hollow Fibre Bioreactor

At the heart of every FiberCell hollow fiber bioreactor system is the Duet Pulsatile Pump. This is integrated into a compact platform that supports one or two independent FiberCell cartridge modules with associated media reservoirs. The system conveniently fits inside a standard CO2 incubator. Robust, durable, quietly efficient and affordable, the Duet Pump is a good investment for any lab getting serious about in-house scale-up of secreted products from mammalian cells [learn more].

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Monoclonal antibody production

Continuous culture of 10^9 hybridomas in a 20ml hollow fibre cartridge on the shelf of a standard incubator [more]

Extracellular vesicle production

3-Capillary Bioreactor conditions are ideal for continuously culturing MSCs or cell lines and taking repeated harvests of very concentrated EVs [more].

Recombinant protein production

Looking to produce a difficult-to-express protein? A Medium Size hollow fibre cartridge (20ml) can generate 2mg per day over many weeks, even months, with 50 x better yield than traditional static flask culture. [more].

Hollow fibre cartridge modules

Pre-sterilized, single-use hollow fibre cartridge modules 3ml, 20ml and 70ml, available in 5 kD, 20 kD MWCO. Special 0.1 µm endothelial cell cartridge also available. [learn more].