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Maintain over 1e9 mammalian cells on the shelf of an incubator and produce multiple supernatant harvests with exceptionally high yields of cell-secreted product

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Latest News from KDBIO
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Protocol for continuous culture of mesenchymal stem cells at high density in a hollow fibre bioreactor to produce concentrated exosomes

For laboratories wishing to produce large amounts of extracellular vesicles (exosomes) from MSCs using a hollow fibre bioreactor, FiberCell Systems has now published a preliminary protocol based on feedback [...]

Media advice for celline flask production of monoclonal antibodies

High density celline flask culture of hybridomas is made more efficient by completely eliminating serum from both compartments. A serum replacement called CDM-HD or "Chemically-Defined Media for High Density [...]

Meet KDBIO at ECI2021 Virtual Exhibition

KDBIO Virtual Exhibition Stand at ECI2021 IN YOUR OWN LAB - produce significant amounts of monoclonal antibodies, recombinant proteins or extracellular vesicles using a FiberCell hollow fibre bioreactor. [...]

EZ-Flask: Culturing hybridoma cell lines for monoclonal antibody production

Culturing hybridoma cell lines for monoclonal antibody production in EZ-Flask saves user time, incubator space and provides easy and economical protein expression. Below you will find detailed [...]

Development of monoclonal antibody using G-Rex Plates

In this example, here are the results of the development of monoclonal antibody for 10 newly developed monoclonal cell lines. Following the successful fusion, clone selection and weaning from [...]

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FiberCell Applications

The FiberCell Hollow Fibre Bioreactor is a compact system for continuous high cell density culture and is used by academic and commercial labs for scaling up production of mAb, protein, exosomes or virus.

Other applications include antimicrobial PK/PD modelling, production of conditioned media, cell secretome, and cultivation of cells continuously to establish 3D in vitro models.

Compact Hollow Fibre Bioreactor

Maintain >10^9 cells in continuous culture on one shelf of a standard incubator. Based on a single-use hollow fibre cartridge module with built-in gas exchanger.

Productivity example: 500mg – 1000mg mAb in 10 weeks in a volume of only 700ml..

CALL US ON : +44-5603-854-110 or +33-388-261-286

Monoclonal antibody production

Continuous culture of 10^9 hybridomas in a 20ml hollow fibre cartridge on the shelf of a standard incubator [more]

Extracellular vesicle production

3-Capillary Bioreactor conditions are ideal for continuously culturing MSCs or cell lines and taking repeated harvests of very concentrated EVs [more].

Recombinant protein production

Looking to produce a difficult-to-express protein? A Medium Size hollow fibre cartridge (20ml) can generate 2mg per day over many weeks, even months, with 50 x better yield than traditional static flask culture. [more].

Hollow fibre cartridge modules

Pre-sterilized, single-use hollow fibre cartridge modules 3ml, 20ml and 70ml, available in 5 kD, 20 kD MWCO. Special 0.1 µm endothelial cell cartridge also available. [learn more].