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Maintain over 1e9 mammalian cells on the shelf of an incubator and produce multiple supernatant harvests with exceptionally high yields of cell-secreted product

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Meet KDBIO at ECI2021 Virtual Exhibition

KDBIO Virtual Exhibition Stand at ECI2021 IN YOUR OWN LAB - produce significant amounts of monoclonal antibodies, recombinant proteins or extracellular vesicles using a FiberCell hollow fibre bioreactor. [...]

EZ-Flask bioreactor – Powerful technology in a simple cell culture flask

The EZ-Flask bioreactor saves user time, incubator space and provides easy and economical protein expression from any suspension cell line. Below you will find detailed descriptions of the major [...]

Monoclonal antibody development using G-Rex Plates

In this example : monoclonal antibody development results for 10 newly developed monoclonal cell lines. Following successful fusion, clone selection and weaning from media supplements ten candidate clones were [...]

EV Core Poster

Comparison of Production and Activity of Amniotic Fluid Stem Cell Extracellular Vesicles from 3D Hollow Fiber Bioreactor and 2D culture. ISEV2020 Poster Laura Perin et al. [...]

Scaling up production of Netrin-1 for structural biology, functional and biophysical studies

Homogenous overexpression of the extracellular matrix protein Netrin-1 in a hollow fiber bioreactor Applied Microbiology and Biotechnology August 2021 https://doi.org/10.1007/s00253-021-11438-0 Aniel Moya-Torres et al. Key Points: Hollow fiber bioreactor produces [...]

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FiberCell Applications

The FiberCell Hollow Fibre Bioreactor is a compact system for continuous high cell density culture and is used by academic and commercial labs for scaling up production of mAb, protein, exosomes or virus.

Other applications include antimicrobial PK/PD modelling, production of conditioned media, cell secretome, and cultivation of cells continuously to establish 3D in vitro models.

Compact Hollow Fibre Bioreactor

Maintain >10^9 cells in continuous culture on one shelf of a standard incubator. Based on a single-use hollow fibre cartridge module with built-in gas exchanger.

Productivity example: 500mg – 1000mg mAb in 10 weeks in a volume of only 700ml..

CALL US ON : +44-5603-854-110 or +33-388-261-286

Monoclonal antibody production

Continuous culture of 10^9 hybridomas in a 20ml hollow fibre cartridge on the shelf of a standard incubator [more]

Extracellular vesicle production

3-Capillary Bioreactor conditions are ideal for continuously culturing MSCs or cell lines and taking repeated harvests of very concentrated EVs [more].

Recombinant protein production

Looking to produce a difficult-to-express protein? A Medium Size hollow fibre cartridge (20ml) can generate 2mg per day over many weeks, even months, with 50 x better yield than traditional static flask culture. [more].

Hollow fibre cartridge modules

Pre-sterilized, single-use hollow fibre cartridge modules 3ml, 20ml and 70ml, available in 5 kD, 20 kD MWCO. Special 0.1 µm endothelial cell cartridge also available. [learn more].