Latest News from KDBIO
piggyBac transposon-based expression system in combination with FiberCell hollow fibre bioreactor enables remarkable levels of production of HexM expression
100 x increase in protein yield accelerates ERT preclinical research Preclinical studies with potential therapeutic recombinant proteins can be hampered by difficulties with expression and scale-up in the laboratory. [...]
Improving the Drug Development Pipeline for Mycobacteria
[Review] Modelling Antibiotic Exposure in the Hollow Fibre Infection Model Maitra, A.; Solanki, P.;Sadouki, Z.; McHugh, T.D.;Kloprogge, F. Improving the Drug Development Pipeline for Mycobacteria: Modelling Antibiotic Exposure in [...]
Protocol for continuous culture of mesenchymal stem cells at high density in a hollow fibre bioreactor to produce concentrated exosomes
For laboratories wishing to produce large amounts of extracellular vesicles (exosomes) from MSCs using a hollow fibre bioreactor, FiberCell Systems has now published a preliminary protocol based on feedback [...]
Media advice for celline flask production of monoclonal antibodies
High density celline flask culture of hybridomas is made more efficient by completely eliminating serum from both compartments. A serum replacement called CDM-HD or "Chemically-Defined Media for High Density [...]
Meet KDBIO at ECI2021 Virtual Exhibition
KDBIO Virtual Exhibition Stand at ECI2021 IN YOUR OWN LAB - produce significant amounts of monoclonal antibodies, recombinant proteins or extracellular vesicles using a FiberCell hollow fibre bioreactor. [...]
FiberCell Applications
The FiberCell Hollow Fibre Bioreactor is a compact system for continuous high cell density culture and is used by academic and commercial labs for scaling up production of mAb, protein, exosomes or virus.
Other applications include antimicrobial PK/PD modelling, production of conditioned media, cell secretome, and cultivation of cells continuously to establish 3D in vitro models.
Compact Hollow Fibre Bioreactor
Maintain >10^9 cells in continuous culture on one shelf of a standard incubator. Based on a single-use hollow fibre cartridge module with built-in gas exchanger.
Productivity example: 500mg – 1000mg mAb in 10 weeks in a volume of only 700ml..
CALL US ON : +44-5603-854-110 or +33-388-261-286
• GEN Tutorial: Hollow Fibers Enhance Protein Expression
• An HFBR Allows Any Lab to Efficiently Express Rec. Proteins in Mammalian Cells (2017)
• Production of Monoclonal Antibodies from Hybridomas in an HF Bioreactor (2017)
• 3D Cell Culture in HF Bioreactors
• Continuous Production of Exosomes (GEN, 2015)
• Interest in Hollow Fiber Perfusion Bioreactors is Growing – (BioProcess International, 2009)
• ISEV Poster – Clinical Scale Production and Wound Healing Activity of Human Adipose Derived MSC EV’s from a Hollow Fiber Bioreactor…
• ISEV 2016 Poster – Large Scale Production of EVs in a Hollow Fiber Bioreactor
• FiberCell Systems Poster – Continuous Collection of Stem Cells from a Human Placenta Perfusion Co-Culture
• ZenBio Poster – Scalable production of exosomes and their potential use as a therapeutic for tendinopathy
• Fast and Efficient Production of Monoclonal Antibodies
• Produce Well-Folded and Glycosylated Recombinant Proteins
• Efficient Production of Extracellular Vesicles / Exosomes
• CDM-HD Chemically Defined Media for High Density Cultures
• FiberCell Systems Brochure
• VIDEO – Setting up a FiberCell Systems bioreactor prior to inoculation of cells
• VIDEO – Inoculating cells into cartridge
• VIDEO – Preparing CDM-HD chemically defined serum replacement
• VIDEO – Standard harvesting procedure – “Low Glucose Rate”
• VIDEO – Reducing cell mass as required – “High Glucose Rate Harvest”
• FiberCell Systems YouTube Channel”
Check out our recent technical emailers
Hollow fibre cartridge modules
Pre-sterilized, single-use hollow fibre cartridge modules 3ml, 20ml and 70ml, available in 5 kD, 20 kD MWCO. Special 0.1 µm endothelial cell cartridge also available. [learn more].
FiberCell Systems Brochure PDF Download
