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BioBUZZ on FiberCell

BioBUZZ Article about hollow fibre culture of cells "If you’ve worked in cell culture, you’ve surely had experience dealing with tissue culture flasks. These plastic vessels are the staple of cell culture work, but they definitely have their share of shortcomings. Having to transfer your cells to gradually larger flasks to scale up. Carefully [...]

By |2022-04-26T12:47:39+00:00April 26th, 2022|blog|0 Comments

July 2020 publication refers to EV production in hollow fibre bioreactor

Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming Alek Mazumdar et al., Dept. of Orthopedics, Balgrist University Hospital, Zurich, Switzerland; Int. J. Mol. Sci. 2020, 21, 5451; doi:10.3390/ijms21155451 "....our findings provide novel insights into the functional relevance of EV-mediated communication between osteosarcoma cells and normal pulmonary fibroblasts. We deliver strong evidence that osteosarcoma cell-derived EVs [...]

By |2021-02-04T08:35:13+00:00September 2nd, 2020|blog|0 Comments

In pursuit of biological specificity

Which culture method is best to generate reagents with native biological specificity? Cell culture methods vary a lot with respect to their ability to generate secreted proteins and antibodies that possess true biological specificity. Culture methodology is therefore a critical consideration for a manufacturer of serological test kits where excellent specificity is a priority. [...]

By |2021-02-04T08:35:13+00:00April 14th, 2020|blog|0 Comments

SARS-CoV-2 and hollow fibre bioreactor culture

Here's how hollow fibre culture could be useful for Coronavirus research. FIRSTLY - Efficient routine production (100mg to grams) of recombinant viral proteins and monoclonal antibodies for TEST KITS to assess the immune response to SARS-CoV-2 in the population. Also, mAbs for the quantification and characterisation of VACCINES prior to lot release : [...]

By |2021-02-04T08:35:13+00:00March 16th, 2020|blog|0 Comments

4th Next-Gen Immuno-Oncology Congress, London, March 12-13th

Meet KDBIO at the 4th Annual MarketsandMarkets Next Gen Immuno-Oncology Congress to discuss production of "difficult-to-express" mAbs and other proteins using continuous high density cell culture for more "in-vivo like" culture conditions. https://events.marketsandmarkets.com/4th-annual-marketsandmarkets-next-gen-immuno-oncology-congress/

By |2021-02-04T08:35:13+00:00January 6th, 2020|Events|0 Comments

ECCMID, April 18th – 21st, Paris

ECCMID 2020, Paris Come to the KDBIO booth at ECCMID to discuss the hollow fibre system for: 1) precise in-vitro modelling of human PK and analysis of pharmacodynamics as well as following the development of resistance over time and in response to different drug combination treatments 2) Efficient production of mAb and rec. proteins [...]

By |2021-10-29T07:54:12+00:00January 4th, 2020|Events|0 Comments

New Publication – Exosomes from ucMSCs – Osteochondral Regeneration

Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity Abstract: Animal and clinical studies have shown that mesenchymal stem cells (MSCs) play an important role in cartilage repair. The therapeutic effect of mesenchymal stem cells based therapies has been increasingly demonstrated to exosome-mediated paracrine [...]

By |2021-02-04T08:35:16+00:00January 4th, 2020|blog|0 Comments
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