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Meet KDBIO at ECI2021 Virtual Exhibition

KDBIO Virtual Exhibition Stand at ECI2021 IN YOUR OWN LAB - produce significant amounts of monoclonal antibodies, recombinant proteins or extracellular vesicles using a FiberCell hollow fibre bioreactor. See also EZ-Flask for growing high numbers of hybridomas without passaging.

By |2021-09-02T05:30:46+00:00September 1st, 2021|Events|0 Comments

Monoclonal antibody development using G-Rex Plates

In this example : monoclonal antibody development results for 10 newly developed monoclonal cell lines. Following successful fusion, clone selection and weaning from media supplements ten candidate clones were transfered to wells of G-Rex 6 Well Plates (35ml media per well, and 10cm2 gas exchange membrane per well). Cell culture supernatant was purified with [...]

By |2021-09-15T10:08:04+00:00August 19th, 2021|News|0 Comments

EV Core Poster

Comparison of Production and Activity of Amniotic Fluid Stem Cell Extracellular Vesicles from 3D Hollow Fiber Bioreactor and 2D culture. ISEV2020 Poster Laura Perin et al. ;Introduction: EV clinical translation is limited by scale-up of EVs production. Hollow fiber bioreactors (HFBR) support culture of large numbers of cells at high densities. [...]

By |2021-08-12T08:59:16+00:00August 12th, 2021|News|0 Comments

Scaling up production of Netrin-1 for structural biology, functional and biophysical studies

Homogenous overexpression of the extracellular matrix protein Netrin-1 in a hollow fiber bioreactor Applied Microbiology and Biotechnology August 2021 https://doi.org/10.1007/s00253-021-11438-0 Aniel Moya-Torres et al. Key Points: Hollow fiber bioreactor produces substantial yields of homogenous Netrin-1 High production yields in the bioreactor do not impair Netrin-1 proteoglycan quality [...]

By |2021-09-15T10:26:39+00:00August 11th, 2021|News|0 Comments

U-Cytech Switches to FiberCell for mAb Production

U-CyTech biosciences switches from roller bottles to FiberCell Systems Hollow Fibre Bioreactor U-CyTech biosciences is based in Utrecht, the Netherlands, and produces a wide range of innovative cytokine ELISA, ELISPOT and Fluorospot systems (human, monkey, rodent). Productions of monoclonal antibody with hybridomas are now performed at U-CyTech’s Utrecht laboratory using the FiberCell Hollow Fibre [...]

By |2021-06-15T09:52:03+00:00June 15th, 2021|News|0 Comments

Monoclonal antibody production comparision in G-Rex, EZ-Flask and FiberCell C2011 Cartridge.

Monoclonal antibody production (hybridoma) in different systems Monoclonal antibody production can be achieved using various culture systems. Depending on the yield you are looking for you might need a different type of system. KDBIO offers 3 scale-up cell culture systems from small batch quantities up to continuous gram production quantities. Below you will find a [...]

By |2021-09-03T09:32:11+00:00June 14th, 2021|News|0 Comments

Meet us at ISEV2021

ISEV2021 provides a great opportunity to discuss 3D CM-EVs production Large amounts of EVs can be obtained from practically any type of cell, including mesenchymal stems cells, maintained over a few weeks at high density in a FiberCell Hollow Fibre Bioreactor. A medium size 20ml hollow fibre cartridge (C2011) offers 4000cm2 of porous fibre surface [...]

By |2021-05-17T16:29:55+00:00May 17th, 2021|Events|0 Comments

New YouTube Channel

New YouTube Channel - Hollow fibre bioreactor technology and applications KDBIO has launched a Youtube channel with short videos to explain hollow fibre bioreactor technology and the advantages this offers for various applications. KDBIO YouTube Channel  

By |2021-02-09T13:55:26+00:00February 5th, 2021|News|0 Comments

YouTube video about CDM-HD

CDM-HD : chemically-defined media for high density culture Once cells are growing at high density in a FiberCell bioreactor it is generally very easy to switch over to CDM-HD (DMEM/10%CMD-HD) which is ideal for generating cell-secreted products such as monoclonal antibodies or extracellular vesicles.

By |2021-02-04T08:35:13+00:00October 13th, 2020|News|0 Comments
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