1) No passaging required
The G-Rex cell culture plates enable the expansion of non-adherent cells to very high numbers without the need for passaging. The production of monoclonal antibodies by hybridoma technology is perfectly suited within the G-Rex plates.
For example, when comparing candidate hybridoma clones, a 35ml well of a G-Rex 6 Plate, without optimisation, might yield 3 – 6 x more monoclonal antibody than a T-175 flask.
2) Gas permeable base membrane
A gas-permeable silicone membrane at the base of each well ensures cells are oxygenated despite the deep well design.
The only limitation on cell proliferation is the volume and type of media. Each well in a G-Rex cell culture plate behaves like a “mini bioreactor”.
Each well base has a surface area of 10cm2. This allows for increased oxygenation and proliferation and thus a higher production of monoclonal antibodies.