Mass production of
uniform spheroids

Routinely produce up to 20,184 uniformly sized spheroids per plate…with minimal effort.

Innovative “microwells-in-macrowell” technology (Kugelmeiers Ltd, patented) enables easy mass-production or screening with uniformly sized spheroids. Spheroids can be scaled from hundreds for laboratory research, up to millions for tissue engineering / regenerative medicine applications. Designed to meet rigorous medical and regulatory requirements, the technology provides an adaptable platform to support your critical diagnostic or clinical projects. It guarantees standardized, uniformly sized spheroids even at large scale, with the handling advantage of easily changing media without disturbing the spheroids.

2400 spheroids per plate = 200 per strip / 25 per well

NEW : This plate has 96 square wells with 25 spheroids per well (up to 500µm dia.) in 12 x 8-well removable strips. The SP5D 96 format plate (KDK096) is designed for researchers in the field of precision oncology working with patient derived cells where source material is limited and lacking homogeneity. Obtain greater statistical validity of results with less effort.

SP5D 96well format spheroid plate for 2400 spheroids

KDK096 SP5D 96-Well Plate (25 microwells per well)

9000 spheroids per plate

A spheroid plate with round-bottomed microwells. The SP5D 24 well format plate (KDK024) has 24 wells with 750 spheroids per well in 2 rows, with 2 rows for 2D culture. Maximum spheroid diameter 150µm.

KDK024 SP5D 24-Well Plate (750 microwells per macrowell)

20,184 spheroids per plate

NEW : A spheroid plate with microwells for easy scale-up of 3D culture. The SP5D 6-well plate with square wells (KDK006) is used to produce 3364 uniform spheroids per well and a total of 20184 spheroids per plate. Maximum spheroid diameter 150µm.

KDK006 SP5D 6-Well Plate (3364 microwells per macrowell)

Technical advantages of SP5D plates

    Rounded bottom of microwell for optimal cell aggregation
    No requirement to do an anti-adhesive pre-coating
    Produce many spheroids per pipetting step
    Multiple spheroids in a well share the same media

Patented design of SP5D plates

The design of the microscopic wells with a hemispherical base is optimised to drive the rapid clusturing of cells into rounded spheroids.  A unique nanocoating prevents cells from adhering to the surface. Consistent spheroids are formed, fostering more natural communication between cells.

The SP5D platform is ideal for consistently generating very large numbers of spheroids per plate boosting the statistical relevance of data from patient derived  tumour samples. The platform is also ideal for generating pseudo-islets and spheroids for tissue engineering research.

Publications list here

Cat.#Description
KDK0066 Well Sphericalplate5D – 20,184 spheroids
KDK02424 Well Sphericalplate5D – 9000 spheroids
KDK09696 Well Sphericalplate5D – 2400 spheroids

Related products – nanofibrous scaffolds for 3D culture

Related products – G-Rex plates for T-cell expansion

Complete G-Rex Plates Range