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U-Cytech Switches to FiberCell for mAb Production

U-CyTech biosciences switches from roller bottles to FiberCell Systems Hollow Fibre Bioreactor U-CyTech biosciences is based in Utrecht, the Netherlands, and produces a wide range of innovative cytokine ELISA, ELISPOT and Fluorospot systems (human, monkey, rodent). Productions of monoclonal antibody with hybridomas are now performed at U-CyTech’s Utrecht laboratory using the FiberCell Hollow Fibre [...]

By |2021-06-15T09:52:03+00:00June 15th, 2021|News|0 Comments

Comparison of G-Rex Plates, EZ-Flask and FiberCell C2011 Cartridge

mAb production (hybridoma) in different systems Monoclonal antibody production can be achieved using various culture systems. Below you will find a comparative table showcasing different bioreactors, their features and the advantages they provide. G-Rex 6 Well Plate EZ-Flask FiberCell C2011 Batch or Continuous Batch Batch Continuous Harvest volume 35 ml / well [...]

By |2021-07-21T08:07:50+00:00June 14th, 2021|News|0 Comments

New YouTube Channel

New YouTube Channel - Hollow fibre bioreactor technology and applications KDBIO has launched a Youtube channel with short videos to explain hollow fibre bioreactor technology and the advantages this offers for various applications. KDBIO YouTube Channel  

By |2021-02-09T13:55:26+00:00February 5th, 2021|News|0 Comments

YouTube video about CDM-HD

CDM-HD : chemically-defined media for high density culture Once cells are growing at high density in a FiberCell bioreactor it is generally very easy to switch over to CDM-HD (DMEM/10%CMD-HD) which is ideal for generating cell-secreted products such as monoclonal antibodies or extracellular vesicles.

By |2021-02-04T08:35:13+00:00October 13th, 2020|News|0 Comments

July 2020 publication refers to EV production in hollow fibre bioreactor

Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming Alek Mazumdar et al., Dept. of Orthopedics, Balgrist University Hospital, Zurich, Switzerland; Int. J. Mol. Sci. 2020, 21, 5451; doi:10.3390/ijms21155451 "....our findings provide novel insights into the functional relevance of EV-mediated communication between osteosarcoma cells and normal pulmonary fibroblasts. We deliver strong evidence that osteosarcoma cell-derived EVs [...]

By |2021-02-04T08:35:13+00:00September 2nd, 2020|News|0 Comments

In pursuit of biological specificity

Which culture method is best to generate reagents with native biological specificity? Cell culture methods vary a lot with respect to their ability to generate secreted proteins and antibodies that possess true biological specificity. Culture methodology is therefore a critical consideration for a manufacturer of serological test kits where excellent specificity is a priority. [...]

By |2021-02-04T08:35:13+00:00April 14th, 2020|News|0 Comments

SARS-CoV-2 and hollow fibre bioreactor culture

Here's how hollow fibre culture could be useful for Coronavirus research. FIRSTLY - Efficient routine production (100mg to grams) of recombinant viral proteins and monoclonal antibodies for TEST KITS to assess the immune response to SARS-CoV-2 in the population. Also, mAbs for the quantification and characterisation of VACCINES prior to lot release : [...]

By |2021-02-04T08:35:13+00:00March 16th, 2020|News|0 Comments

New Publication – Exosomes from ucMSCs – Osteochondral Regeneration

Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity Abstract: Animal and clinical studies have shown that mesenchymal stem cells (MSCs) play an important role in cartilage repair. The therapeutic effect of mesenchymal stem cells based therapies has been increasingly demonstrated to exosome-mediated paracrine [...]

By |2021-02-04T08:35:16+00:00January 4th, 2020|News|0 Comments
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