Here’s how hollow fibre culture could be useful for Coronavirus research.
FIRSTLY – Efficient routine production (100mg to grams) of recombinant viral proteins and monoclonal antibodies for TEST KITS to assess the immune response to SARS-CoV-2 in the population.
Also, mAbs for the quantification and characterisation of VACCINES prior to lot release :
https://www.kdbio.com/applications/produce-difficult-to-express-recombinant-protein
SECONDLY – Antimicrobial pharmacodynamics and evaluation of the emergence of resistance. Publications include:
Oseltamivir-zanamivir combination therapy suppresses drug-resistant H1N1 influenza A viruses in the hollow fiber infection model (HFIM) system: Pires de Mello, C.P.; European Journal of Pharmaceutical Sciences 111 (2018) 443-449 [open access]
Azithromycin Pharmacodynamics Against Non-Typeable H. Influenzae: Fisher, J., Yale University Public Health Theses 2016 [open access]
THIRDLY– Production of SARS-CoV-2 virus in the laboratory at high titer
https://www.kdbio.com/applications/references-virus-production.
FOURTHLY – Rapid production of exosomes for inhalation therapy, perhaps, or for novel vaccines:
https://www.kdbio.com/applications/exosome-extracellular-vesicle-production/.
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