FiberCell Hollow Fibre Bioreactor
Continuously culture up to 1e10 mammalian cells in a standard incubator
Proven system for cell culture scale-up
A FiberCell Systems Hollow Fibre Bioreactor gives any laboratory the possibility to significantly scale-up cell culture and generate very large amounts of cell-secreted products. The aim with this kind of system is to establish a steady-state high density culture that generates a very consistent product. Data is available to demonstrate this capability.
All the advantages of hollow fibre cell culture are detailed here. This is a proven cell culture platform described many times in the scientific literature. Lists of scientific publications can be accessed via these links : monoclonal antibodies , extracellular vesicles , recombinant proteins , virus and 3D Culture.
Components / Practical Aspects
The system is based on consumable cartridge modules that are supplied sterile and which can be easily fitted to, and removed from, the DUET pump platform. Autoclavable reservoir caps are supplied for the media reservoir bottle. For product harvesting the cartridge with its media reservoir are taken to the laminar flow cabinet while the DUET pump remains always in the incubator. See the cartridge selection guide here.
Request a personalized hollow fibre culture training package with your system : Cat.# QS-ZOOM
Using 3-D cell culture systems to overcome barriers in recombinant protein production
Production of monoclonal antibodies from hybridomas in a hollow fibre bioreactor
Interest in Hollow Fiber Perfusion Bioreactors is Growing – (BioProcess International, 2009)
ISEV Poster – Retroviral Transduction and Production of Palm-GRET Labelled Extracellular Vesicles using Bone Marrow Derived MSC in a Hollow Fiber Bioreactor
ISEV Poster – Scalability of Production and Bio-Activity of Amniotic Fluid Stem Cell Extracellular Vesicles from 3-D Hollow Fiber Bioreactor and 2-D Culture
ISEV Poster – Clinical Scale Production and Wound Healing Activity of Human Adipose Derived MSC EV’s from a Hollow Fiber Bioreactor…
ISEV 2016 Poster – Large Scale Production of EVs in a Hollow Fiber Bioreactor
FiberCell Systems Poster – Continuous Collection of Stem Cells from a Human Placenta Perfusion Co-Culture
ZenBio Poster – Scalable production of exosomes and their potential use as a therapeutic for tendinopathy
VIDEO – Setting up a FiberCell Systems bioreactor prior to inoculation of cells
VIDEO – Preparing CDM-HD chemically defined serum replacement
VIDEO – Reducing cell mass as required – “High Glucose Rate Harvest”