Hollow fibre bioreactor
FiberCell Systems Laboratory-Scale Hollow Fibre Bioreactor (fits on shelf of incubator)

A FiberCell Systems Hollow Fibre bioreactor enables the continuous culture of large numbers of cells at high density. It’s a time-scalable production process that’s ideal for generating significant amounts of very concentrated EVs/exosomes, mAbs or recombinant proteins. Projects to generate grams of monoclonal antibody have been successfully managed with this system, for example, in cell culture laboratories furnished with standard facilities.
The cartridge and media reservoir form a closed loop that can easily be decoupled from the Duet pump and transferred to a laminar flow cabinet for harvesting and media changes. Using syringes, product-enriched supernatant can be periodically collected from the cell compartment. The molecular weight cut-off of the hollow fibres traps and concentrates secreted products to give very high yields. Up to 100X greater product concentration than with flask culture is routinely possible.


Advantages of Hollow Fibre Culture


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