The Effect of Drug Combinations on the Kinetics of the Emergence of Antibiotic Resistance in E. coli CFT073 Using the In Vitro Hollow Fiber Infection Model Abstract: Antibiotic resistance is one of the major threats to public health today. To address this problem requires an urgent comprehensive approach. Strategic and multi-targeted combination therapy [...]
In Vitro Culture of Cryptosporidium parvum Using Hollow Fiber Bioreactor: Applications for Simultaneous Pharmacokinetic and Pharmacodynamic Evaluation of Test Compounds Abstract: Hollow fiber technology is a powerful tool for the culture of difficult-to-grow cells. Cryptosporidium parvum has a multistage sexual and asexual life cycle that has proved difficult to culture by conventional in vitro [...]
KDBIO exhibition booth at BSI 2019, Liverpool Thanks to the immunologists who stopped at the KDBIO booth during BSI 2019 to discuss their future in-house projects for production of cytokines, recombinant vaccines, monoclonal antibodies and exosomes. The FiberCell bioreactor is ideal for immunology labs wanting to generate monoclonal antibody in the range 100 mg [...]
Interested in producing EVs from cells in continuous high density culture? Meet us in Freising. KDBIO will be showing the FiberCell hollow fibre bioreactor and available to discuss the latest information about growing cells around porous fibres that are dynamically perfused with media. In this mode of culture EVs are retained and concentrated by [...]
Publication refers to use of FiberCell Bioreactor : Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin Α5β1 Is a Modulator of Extravillous Trophoblast Functions. "PSG1‐Fc, PSG1‐His, PSG1N‐Fc and the proteins used interchangeably as negative controls, Fc and CEACAM9‐Fc, were generated from the supernatant of stably transfected CHO‐K1 single‐cell clones established in our laboratory and grown in [...]
KDBIO exhibiting at GEIVEX 2019 in Granada Large amounts of EVs can be obtained from practically any type of cell, including mesenchymal stems cells, maintained over a few weeks at high density in a FiberCell Hollow Fibre Bioreactor. A medium size 20ml hollow fibre cartridge (C2011) permits periodic collection of 20mls of exosome-enriched [...]
KDBIO exhibits at FSEV_2019 and BESEV_2019 Thanks to the organisers of the FSEV and BESEV meetings in Nantes and Leuven during the week of 14th October 2019. A busy week for exhibitors! Thanks also to researchers who were curious to learn about exosome production using the FiberCell System and who visited the KDBIO table. Some [...]
Recent publications mentioning the FiberCell Hollow Fibre Bioreactor for producing exosomes with urine derived stem cells: Urine-derived stem cells facilitate endogenous spermatogenesis restoration of busulfan-induced non-obstructive azoospermic mice by paracrine exosomes. Cuncan DengYun Xie et al.; Stem Cells and Development (Jul 16 2019) [abstract]... "Our data demonstrated that transplantation of USC‐exos was able to [...]
KDBIO will be present with an exhibition stand at the 9th European Conference on Tetraspanins Proteins from the tetraspanin superfamily are among the most abundant membrane proteins of EVs. For tetraspanin researchers interested in generating large amounts of EVs in small, regular harvest volumes from cells in continuous culture the FiberCell Hollow Fibre Bioreactor [...]
Hollow fibre bioreactor for EV production - practical session for 50 students on 17th July KDBIO will attend the UKEV Summer School 2019 on 17th July to give an introductory hands-on training to 50 student participants with the objective of introducing the key aspects of cell culture in a hollow fibre bioreactor. Large amounts [...]