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July 2020 publication refers to EV production in hollow fibre bioreactor

Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming Alek Mazumdar et al., Dept. of Orthopedics, Balgrist University Hospital, Zurich, Switzerland; Int. J. Mol. Sci. 2020, 21, 5451; doi:10.3390/ijms21155451 "....our findings provide novel insights into the functional relevance of EV-mediated communication between osteosarcoma cells and normal pulmonary fibroblasts. We deliver strong evidence that osteosarcoma cell-derived EVs [...]

By |2021-02-04T08:35:13+00:00September 2nd, 2020|News|0 Comments

In pursuit of biological specificity

Which culture method is best to generate reagents with native biological specificity? Cell culture methods vary a lot with respect to their ability to generate secreted proteins and antibodies that possess true biological specificity. Culture methodology is therefore a critical consideration for a manufacturer of serological test kits where excellent specificity is a priority. [...]

By |2021-02-04T08:35:13+00:00April 14th, 2020|News|0 Comments

SARS-CoV-2 and hollow fibre bioreactor culture

Here's how hollow fibre culture could be useful for Coronavirus research. FIRSTLY - Efficient routine production (100mg to grams) of recombinant viral proteins and monoclonal antibodies for TEST KITS to assess the immune response to SARS-CoV-2 in the population. Also, mAbs for the quantification and characterisation of VACCINES prior to lot release : [...]

By |2021-02-04T08:35:13+00:00March 16th, 2020|News|0 Comments

4th Next-Gen Immuno-Oncology Congress, London, March 12-13th

Meet KDBIO at the 4th Annual MarketsandMarkets Next Gen Immuno-Oncology Congress to discuss production of "difficult-to-express" mAbs and other proteins using continuous high density cell culture for more "in-vivo like" culture conditions. https://events.marketsandmarkets.com/4th-annual-marketsandmarkets-next-gen-immuno-oncology-congress/

By |2021-02-04T08:35:13+00:00January 6th, 2020|Events|0 Comments

ECCMID, April 18th – 21st, Paris

ECCMID 2020, Paris Come to the KDBIO booth at ECCMID to discuss the hollow fibre system for: 1) precise in-vitro modelling of human PK and analysis of pharmacodynamics as well as following the development of resistance over time and in response to different drug combination treatments 2) Efficient production of mAb and rec. proteins [...]

By |2021-02-04T08:35:16+00:00January 4th, 2020|Events|0 Comments

New Publication – Exosomes from ucMSCs – Osteochondral Regeneration

Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity Abstract: Animal and clinical studies have shown that mesenchymal stem cells (MSCs) play an important role in cartilage repair. The therapeutic effect of mesenchymal stem cells based therapies has been increasingly demonstrated to exosome-mediated paracrine [...]

By |2021-02-04T08:35:16+00:00January 4th, 2020|News|0 Comments

In vitro PK/PD – new publication from FDA – drug combos – E. coli CFT073

The Effect of Drug Combinations on the Kinetics of the Emergence of Antibiotic Resistance in E. coli CFT073 Using the In Vitro Hollow Fiber Infection Model Abstract: Antibiotic resistance is one of the major threats to public health today. To address this problem requires an urgent comprehensive approach. Strategic and multi-targeted combination therapy [...]

By |2021-02-04T08:35:17+00:00January 4th, 2020|News|0 Comments

In vitro PK/PD – New publication in “Cryptosporidium”

In Vitro Culture of Cryptosporidium parvum Using Hollow Fiber Bioreactor: Applications for Simultaneous Pharmacokinetic and Pharmacodynamic Evaluation of Test Compounds Abstract: Hollow fiber technology is a powerful tool for the culture of difficult-to-grow cells. Cryptosporidium parvum has a multistage sexual and asexual life cycle that has proved difficult to culture by conventional in vitro [...]

By |2021-02-04T08:35:17+00:00January 4th, 2020|News|0 Comments
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