Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection model: Lodise et al.; Journal of Antimicrobial Chemotherapy, Volume 75, Issue 9, September 2020, Pages 2622–2632 [abstract]

Comparison of a novel regimen of rifapentine, tedizolid, and minocycline with standard regimens for treatment of the pulmonary Mycobacterium kansasii: Chapagain M. et al.; Antimicrob. Agents Chemother. July 2020 [abstract]

Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against Pseudomonas aeruginosa in a dynamic in vitro hollow-fibre infection model: Heffernan A.J. et al.; Antimicrob. Agents Chemother. July 2020 [abstract]

Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae: Chandra Datta Sumi et al.; Journal of Antimicrobial Chelotherapy June 2020 [abstract]

Modeling of Effective Antimicrobials to Reduce Staphylococcus aureus Virulence Gene Expression Using a Two‐Compartment Hollow Fiber Infection Model: Shukla, S.K. et al Toxins vol. 12 (2) 2020 [open access]

The Effect of Drug Combinations on the Kinetics of the Emergence of Antibiotic Resistance in E. coli CFT073 Using the In Vitro Hollow Fiber Infection Model: Garimella, N. et al, Antimicrobial Agents Dec 2019 [abstract]

Fluconazole Monotherapy Is a Suboptimal Option for InitialTreatment of Cryptococcal Meningitis Because of Emergenceof Resistance: Hope, W. et al, Therapeutics and Preventation Nov-Dec 2019 [open access]

Mimicking in-vivo exposures to drug combinations in-vitro: antituberculosis drugs in lung lesions and the hollow fiber model of infection: Kloprogge, F. et al, 13 Sep 2019 [open access]

P-glycoprotein mediated efflux reduces the in vivo efficacy of a therapeutic targeting the gastrointestinal parasite Cryptosporidium: Arnold SLM et al; J Infect Dis. 2019 Jun 8. [open access]

Pharmacodynamics of 1 Ceftazidime plus Avibactam against KPC-2 Bearing Isolates of Klebsiella pneumoniae in a Hollow Fiber Infection Model: Drusano GL et al; Antimicrob Agents Chemother. 2019 Jun 3 [abstract]

Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans: Antimicrobial Agents and Chemotherapy May 2019 Vol 63 Issue 5 [open access]

Comparison of in vitro static and dynamic assays to evaluate the efficacy of an antimicrobial drug combination against Staphylococcus aureus: Broussou, D. et al; PLOS ONE Jan 2019 [open access]

Clinical Regimens of Favipiravir Inhibit Zika Virus Replication in the Hollow-Fiber Infection Model: Camilly P. Pires de Mello et al.; Antimicrob Agents Chemother 2018 62 [abstract]

Differential Activity of the Combination of Vancomycin and Amikacin on Planktonic vs. Biofilm-Growing Staphylococcus aureus Bacteria in a Hollow Fiber Infection Model: Broussou, D. et al; Front. Microbiol., 27 March 2018 [open access]

Optimization and evaluation of piperacillin plus tobramycin combination dosage regimens against Pseudomonas aeruginosa for patients with altered pharmacokinetics via the hollow-fiber infection model and mechanism-based modelling: Yadav, R. et al; AMS 2018 (62) 3 [abstract]

Evaluation of Activity and Emergence of Resistance of Polymyxin B and ZTI-01 (Fosfomycin for Injection) against KPC-Producing Klebsiella pneumoniae: Diep, J.K. et al; Antimicrob. Agents Chemother. 2018 (62) 2 [open access]

Oseltamivir-zanamivir combination therapy suppresses drug-resistant H1N1 influenza A viruses in the hollow fiber infection model (HFIM) system: Pires de Mello, C.P.; European Journal of Pharmaceutical Sciences 111 (2018) 443-449 [open access]

Polymyxin Combinations Combat Escherichia coli Harboring mcr-1 and blaNDM-5: Preparation for a Postantibiotic Era. Bulman Z.PP; mBio 8(4)2017 [open access]

In vitro pharmacodynamic evaluation of ceftolozane/tazobactam against β-lactamase-producing Escherichia coli in a hollow-fibre infection model Soon, R et al. International Journal of Antimicrobial Agents 2017 49(1)[open access]

From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modeling. Drusano G.L.; Bioorg Med Chem. 2016[abstract]

Linezolid for Infants and Toddlers With Disseminated Tuberculosis: First Steps: Deshpande, D. et al.; Clin Infect Dis. 2016, 63 (3)S80-87 [abstract]

Concentration-Dependent Synergy and Antagonism of Linezolid and Moxifloxacin in the Treatment of Childhood Tuberculosis: The Dynamic Duo: Deshpande, D. et al.; Clin Infect Dis. 2016, 63 (3): S88-S94.[open access]

A Faropenem, Linezolid, and Moxifloxacin Regimen for Both Drug-Susceptible and Multidrug-Resistant Tuberculosis in Children: FLAME Path on the Milky Way: Deshpande, D. et al.; Clin Infect Dis. 2016, 63(3): S95-S101.: S88-S94.[open access]

Thioridazine as Chemotherapy for Mycobacterium avium Complex Diseases: Deshpande, D. et al.; Antimicrob. Agents Chemother. 2016 60 (8) 4652-4658 [open access]

Azithromycin Pharmacodynamics Against Non-Typeable H. Influenzae: Fisher, J., Yale University Public Health Theses 2016 [open access]

EMA Qualification opinion: In-vitro hollow fiber system model of tuberculosis (HSF-TB): EMA/CHMP/SAWP/47290/2015

Continuous culture of Cryptosporidium parvum using hollow fiber technology: Morada, M. et al.; Int J Parasitol. 2016 Jan;46(1):21-9 [related presentation PDF]

A long-term Co-perfused Disseminated Tuberculosis-3D Liver Hollow Fiber Model for Both Drug Efficacy and Hepatotoxicity in Babies: Srivastava, S. et al.; EBioMedicine 2016; 6:126-138 [open access]

Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy: Brown, A. et al.; mBio vol. 6 (6) [open access]

Strategic Regulatory Evaluation and Endorsement of the Hollow Fiber Tuberculosis System as a Novel Drug Development Tool: Romero, K., Clay, R. and Hanna, D.; Clinical Infectious Diseases 2015 61 (1): S5–9 [open access]

Pharmacokineticdeterminants of virological response to raltegravir in thein vitropharmacodynamic hollow-fiber infection model system: Brown AN, Adams JR, Baluya DL, Drusano G; . Antimicrob AgentsChemother 59:3771–3777 [open access]

In Vitro Pharmacodynamics of Various Antibiotics in Combination against Extensively Drug-Resistant Klebsiella pneumoniae Lim, Tze-Peng et al.; Antimicrobial Agents and Chemother. 2015 59(5): 2515–2524.[open access]

Correlations Between the Hollow Fiber Model of Tuberculosis and Therapeutic Events in Tuberculosis Patients: Learn and Confirm: Gumbo, T.;2015 [open access]

The Hollow Fiber Infection Model: Principles and Practice: Cadwell, J.;J Adv Antibiotics and Antibodies 2015, 1(1) [open access]

Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance:Ly,N.S. et al.; Journal of Antimicrobial Therapy 2015 70(5): 1434-1442 [open access]

Hollow Fiber System Model for Tuberculosis: The European Medicines Agency Experience: Cavaleri, M. and Manolis, E.; Clin Infect Dis. (2015) 61 (suppl 1): S1-S4.[open access]
The in vitro hollow fiber system model has been qualified by the European Medicines Agency as a methodology for use in support of selection and development of antituberculosis regimens. More data are expected to be generated in the future to further characterize its value.

Rapid Drug Tolerance and Dramatic Sterilizing Effect of Moxifloxacin Monotherapy in a Novel Hollow-Fiber Model of Intracellular Mycobacterium kansasii Disease: Srivastava, S. et al.; Antimicrob. Agents Chemother. 2015, 59(4) [open access]

Model System to Define Pharmacokinetic Requirements for Antimalarial Drug Efficacy: Bakshi R., Shapiro A. et al.; Science Translational Medicine 2013:Vol. 5, Issue 205 [open access]

Thioridazine Pharmacokinetic-Pharmacodynamic Parameters “Wobble” during Treatment of Tuberculosis: a Theoretical Basis for Shorter-Duration Curative Monotherapy with Congeners Musuka, S. et al.; Antimicrob. Agents Chemother. 2013 vol. 57 no. 12 5870-5877 [open access]

PK/PD models in antibacterial development: Velkov, T. et al.; Curr Opin Microbiol . 2013, 16(5) [open access]

Hollow-fiber pharmacodynamics studies and mathematical modeling to predict the efficacy of amoxicillin for anthrax postexposure prophylaxis in pregnant women and children. Louie, A et al.; Antimicrob Agents Chemother 2013; 57:5946–60. [open access]

Relationship between Ceftolozane-Tazobactam Exposure and Drug Resistance Amplification in a Hollow-Fiber Infection Model: VanScoy, B. et al.; Antimicrobial Agents and Chemotherapy 2013 p 4134 – 4138. [open access]

The Hollow Fiber Infection Model for Antimicrobial Pharmacodynamics and Pharmacokinetics: Cadwell, J.; Adv Pharmacoepidem Drug Safety 2012 [open access]

In Vitro Activity of MK-7655, a Novel Beta-Lactamase Inhibitor, in Combination With Imipenem Against Carbapenem-Resistant Gram-Negative Bacteria: Hirsch,E.B. et al.; Antimicrobial Agents and Chemotherapy 2012; 56(7): 3753–57 [open access]

Simulated Antibiotic Exposures in an In Vitro Hollow-Fiber Infection Model Influence Toxin Gene Expression and Production in Community-Associated Methicillin-Resistant Staphylococcus aureus Strain MW2: Pichereau, S. et al.; Antimicrob Agents Chemother. 2012 Jan; 56(1): 140–147. [open access]

Effect of Half-Life on the Pharmacodynamic Index of Zanamivir against Influenza Virus Delineated by a Mathematical Model: Brown, A. et al.; Antimicrob. Agents Chemother. 2011 55 (4) 1747-1753[open access]

Antiviral pharmacodynamics in hollow fibre Bioreactors: McSharry, J. et al.; Antiviral Chemistry & Chemotherapy 2011; 21:183–192 [open access]

Pharmacokinetic Mismatch Does Not Lead to Emergence of Isoniazid- or Rifampin-Resistant Mycobacterium tuberculosis but to Better Antimicrobial Effect: a New Paradigm for Antituberculosis Drug Scheduling: Srivastava, S. et al; Antimicrob. Agents Chemother. 2011 55 (11): 5085-5089 [open access]

Moxifloxacin Pharmacokinetics/Pharmacodynamics and Optimal Dose and Susceptibility Breakpoint Identification for Treatment of Disseminated Mycobacterium avium Infection :Deshpande,D. et al.;Antimicrob Agents Chemother. 2010 54(6): 2534–2539. [open access]

Optimizing the Culture of Plasmodium Falciparum in Hollow Fiber Bioreactors :Preechapornkul,P. et al.;Southeast Asian J Trop Med Public Health. 2010 41(4): 761–769 [open access]

Ethambutol Optimal Clinical Dose and Susceptibility Breakpoint Identification by Use of a Novel Pharmacokinetic-Pharmacodynamic Model of Disseminated Intracellular Mycobacterium avium: <>Deshpande, D. et al.; Antimicrob Agents Chemother. 2010 54(5): 1728–1733 [open access]

In Vitro System for Modeling Influenza A Virus Resistance under Drug Pressure: Brown, A.; Antimicrob Agents Chemother. 2010 Aug;54(8):3442-50 open access]

Prediction of the Pharmacodynamically Linked Variable of Oseltamivir Carboxylate for Influenza A Virus Using an In Vitro Hollow-Fiber Infection Model System. McSharry, J.; Antimicrob. Agents Chemother. 2009 53 (6) 2375-2381 open access]

Pharmacodynamics of Cidofovir for Vaccinia Virus Infection in an In Vitro Hollow-Fiber Infection Model System. McSharry, J.; Antimicrob. Agents Chemother. 2009 53(1) 129-135 [open access] – system diagram

Is 60 Days of Ciprofloxacin Administration Necessary for Postexposure Prophylaxis for Bacillus Anthracis?Drusano GL et al. 2008 Antimicrob Agents Chemother 52 (11), 3973- [open access

Pharmacodynamic Characterization of gemcitabine cytotoxicity in an in vitro cell culture bioreactor system. Kirstein MN, Brundage RC, Moore MM, Williams BW, Hillman LA, et al. 2008 Cancer Chemother Pharmacol 61: 291-299.

Comparative Pharmacodynamics of Gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa: Tam, V. et al; Antimicrob Agents Chemother. 2006 50(8): 2626–2631

Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modeling. Gumbo, T. et al.; J Infect Dis. 2004 Nov 1;190(9):1642-51. [open access]