Hollow Fibre Cancer Model for PK/PD
- Simulate the PK concentration-time profiles of compounds; in plasma AND tissue
- Sample from distinct PK (central luminal) and PD (extracapillary) compartments
- Study the emergence of resistance over extended periods
- Test combination regimens
- Co-cultivation of different cell types
References:
Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling of Anti-Neoplastic Agents: Daniel Lexcen, Ahmed Salem, Walid M. El-Khatib, Virginia Haynes and Ayman Noreddin (2012). [download chapter]
Pharmacodynamic characterization of gemcitabine cytotoxicity in an in vitro cell culture bioreactor system: Kirstein et al., Cancer Chemother Pharmacol (2007).[abstract]
Starter kit for PK/PD – oncology
| Cat.# | Description | Qty |
|---|---|---|
| P3202 | FiberCell® Systems Duet | 1 |
| C2011 | High Flux PS Cartridge 20 kDa (3000 cm2 – 20 ml) | 1 |
| A1006 | 38mm Reservoir Cap | 1 |
Please contact us to discuss the best choice of cartridge for testing your compound(s).