Hollow Fibre Cancer Model for PK/PD

  • Simulate the PK concentration-time profiles of compounds; in plasma AND tissue
  • Sample from distinct PK (central luminal) and PD (extracapillary) compartments
  • Study the emergence of resistance over extended periods
  • Test combination regimens
  • Co-cultivation of different cell types

References:

Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling of Anti-Neoplastic Agents: Daniel Lexcen, Ahmed Salem, Walid M. El-Khatib, Virginia Haynes and Ayman Noreddin (2012). [download chapter]

Pharmacodynamic characterization of gemcitabine cytotoxicity in an in vitro cell culture bioreactor system: Kirstein et al., Cancer Chemother Pharmacol (2007).[abstract]

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