Production scale-up with different size cartridge modules
Continuous production process for Exomeres, Exosomes, Extracellular Vesicles, Microvesicles…
Some EV producers find themselves burdened with very large volumes of static flask supernatant to process which can lead to stressful bottlenecks in lab workflow. A FiberCell Hollow Fibre Bioreactor produces very concentrated EVs in a space- and time-efficient manner. Practically any type of cell, including mesenchymal stromal cells, can be cultured continuously at high density in this system. Yield increases of at least 40X compared to flask culture have been reported while the total amount of EVs produced depends on how many weeks the system is operated.
In addition, the 3D capillarised culture environment inside a hollow fibre bioreactor has been shown to be more representative of in vivo conditions compared to flask culture […more].
A Medium Size 20ml FiberCell cartridge (C2011) will support continuous post-confluent growth of 1E+9 cells. Further scale-up is straightforward without the need for new hardware.