CLL cells shown to transmigrate
Data generated by a UK lab using the FiberCell C2025 cartridge and Duet pulsatile pump showed that the system enables a novel, dynamic, and tractable in vitro model of lymphocyte migration. Also the results confirmed that CD49d is a critical regulator of lymphocyte migration in CLL. See reference below.
Consistent and defined shear stress
The microprocessor controlled FiberCell Systems pump can be programmed to produce consistent and defined amounts of shear stress by regulating the flow of medium over the cells. This allows the study of endothelial cells in a more physiologic environment when compared to other methods.
Co-culturing endothelial cells with smooth muscle cells…etc.
The microporous nature of the fibres and the ability to control the extra-cellular matrix provides an ideal system for cellular co-cultivation with other cell types such as vascular smooth muscle or neuroglia.
Attachment of cells to internal walls of fibres
The FiberCell 0.1µm fibres must first be coated with extra-cellular matrix proteins (and/or cytokines and antibodies) to permit the attachment of endothelial cells to the interior wall of the fibre.