Co-cultivation of stromal and erythroleukemia cells
The FiberCell hollow fibre system has been used to construct a bone marrow model by co-cultivating stromal and erythroleukemia cells.
“…The HFBR co-culture resulted in greater leukemic cell expansion (3,130 fold vs. 43 fold) compared to a standard tissue culture polystyrene (TCP) culture. Majority of expanded cells (68%) in HFBR culture were the adherent population, highlighting the importance of cell–cell contact for myelo-leukemic proliferation.”
Co-culture of Stromal and Erythroleukemia Cells in a Perfused Hollow Fiber Bioreactor System as an in vitro Bone Marrow Model for Myeloid Leukemia. Usuludin S, et al.; Biotechnol. Bioeng. 2012 109(5) [open access]