More physiologically relevant conditions
The FiberCell Systems PS+ module (cat# C2025) enables the culture and study of endothelial cells exposed to pulsatile shear stress in an artificial capillary system. Under conditions that closely mimic the in vivo situation, endothelial cells spread out as an endothelium monolayer on the inner surface of the fibres with the formation of tight junctions between cells.
Co-culturing endothelial cells with smooth muscle cells…etc.
The microporous nature of the fibres and the ability to control the extra-cellular matrix provides an ideal system for cellular co-cultivation with other cell types such as vascular smooth muscle or neuroglia.
Attachment of cells to internal walls of fibres
The PS+ fibre is first coated with extra-cellular matrix proteins (and/or cytokines and antibodies) to permit the attachment of endothelial cells to the interior wall of the fibre.
Consistent and defined shear stress
The microprocessor controlled FiberCell Systems pump can be programmed to produce consistent and defined amounts of shear stress by regulating the flow of medium over the cells. This allows the study of endothelial cells in a more physiologic environment when compared to other methods.